Waning and aging of cellular immunity toB. pertussis
نویسندگان
چکیده
منابع مشابه
Pertussis Vaccine Effectiveness and Waning Immunity
A resurgence of pertussis cases among immunized and unimmunized individuals raised questions about vaccine effectiveness and waning immunity. We performed a test-negative case-control study, utilizing Ontario administrative and laboratory data. We used crude and adjusted multivariable logistic regression models to estimate odds ratios (ORs) comparing the odds of cases being vaccinated against t...
متن کاملWaning immunity to pertussis following 5 doses of DTaP.
OBJECTIVE To assess the risk of pertussis by time since vaccination in children in Minnesota and Oregon who received 5 doses of acellular pertussis vaccines (DTaP). METHODS These cohort analyses included Minnesota and Oregon children born between 1998 and 2003 who had 5 DTaP doses recorded in state Immunization Information Systems. Immunization records and statewide pertussis surveillance dat...
متن کاملCellular immunity in pertussis.
Considerable advances have been made recently in our understanding of the pathogenesis and the immunological mechanisms involved in the prevention and control of infection by Bordetella pertussis. Traditionally , research on protection has focused on the role of humoral immunity and several reports have shown that passive transfer of antibodies against several putative protective antigens, incl...
متن کاملImplications of vaccination and waning immunity.
For infectious diseases where immunization can offer lifelong protection, a variety of simple models can be used to explain the utility of vaccination as a control method. However, for many diseases, immunity wanes over time and is subsequently enhanced (boosted) by asymptomatic encounters with the infection. The study of this type of epidemiological process requires a model formulation that ca...
متن کاملModeling rates of infection with transient maternal antibodies and waning active immunity: application to Bordetella pertussis in Sweden.
Serological surveys provide reliable information from which to calculate forces (instantaneous rates) of infection, but waning immunity and clinical consequences that depend on residual immunity complicate interpretation of results. We devised a means of calculating these rates that accounts for passively acquired maternal antibodies that decay or active immunity that wanes, permitting re-infec...
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ژورنال
عنوان ژورنال: Pathogens and Disease
سال: 2015
ISSN: 2049-632X
DOI: 10.1093/femspd/ftv071